Conducts mRNA display and DNA-encoded library screening for cyclic peptide and small-molecule discovery. Responsibilities include designing and analyzing selections, optimizing platform workflows, handling nucleic acids, developing hit-identification assays, analyzing sequencing data, and supporting client projects. The role also contributes to peptide characterization, project planning, documentation, platform innovation, and technology transfer in a biotech or contract research environment.
Overview
We are looking for a Research Scientist with deep expertise in peptide chemistry and chemical biology to help shape and deliver our mRNA display & DNA encoded libraries (DEL) services for external clients. You will work independently on peptide and small molecule discovery projects, refine and work on internal Research & Development. This is a hands-on, scientifically demanding role at the interface of chemistry, molecular biology and client delivery. You will work with a collaborative team of scientists, contribute to platform innovation, and work closely with external partners.
Responsibilities- Design, run and analyze mRNA display selections of cyclic peptide libraries against diverse targets
- Maintain, optimize and extend the mRNA display platform, including library design, translation, cyclisation and selection workflows
- Handle and quality-control nucleic acids (mRNA, DNA, cDNA), including library preparation, PCR/RT-PCR and next-generation sequencing readouts
- Develop, validate and transfer assays for hit identification and confirmation
- Contribute to project planning, timelines and documentation
- Keep abreast of new developments in display technologies and cyclic peptide therapeutics, and propose improvements to our offering
- Contribute to peptide and small-molecule DEL screening projects, including library screening, hit identification and data analysis
- Master in chemistry, chemical biology, biochemistry or equivalent experience
- Proven experience in mRNA display, including screening of cyclic peptide libraries and platform manipulation
- Strong practical skills in nucleic acid handling (mRNA/DNA work, PCR, library construction, sequencing analysis)
- Experience developing and optimizing assays for hit identification and validation
- Excellent written and spoken English
Additional Skills
- Experience in In Vitro peptide macrocyclization, bioconjugation & genetic code reprogramming
- Biophysical assays for binding and affinity (e.g. SPR, BLI, ITC, FP)
- Peptide characterization by LC-MS, HPLC and related analytical methods
- Industry experience in a biotech, pharmaceutical or contract research / service environment, with an understanding of timelines, quality expectations and client delivery
- Experience with DNA encoded libraries
Similar Jobs
Artificial Intelligence • Big Data • Cloud • Software
Generates enterprise SaaS pipeline through outbound prospecting, targeted campaigns, events, and inbound lead qualification. Researches target accounts, engages prospects in German and English, explains technical solutions, and secures qualified meetings for Account Executives. Supports forecasting, CRM and sales technology reporting, pipeline reviews, marketing activity, and SDR training. The role also mentors new representatives, tests outreach strategies, and contributes to process improvements while preparing for future quota-carrying sales responsibilities.
Top Skills:
Ai Prospecting ToolsClaudeCommon RoomGongLinkedInSaaSSalesforce
Artificial Intelligence • Cloud • Computer Vision • Hardware • Internet of Things • Software
Own post-sale customer implementations of Samsara’s IoT technology, from solution workshops and project planning through deployment and time-to-value. Lead change management, training, demonstrations, stakeholder communication, and obstacle resolution across multiple concurrent engagements. Partner cross-functionally with Sales, Support, Sales Engineering, and Product while managing customer relationships and implementation outcomes. The role requires travel to customer sites up to 30% of the time and fluency in English and German.
Top Skills:
AIAutomationHardwareInternet Of Things (Iot)SaaS
Artificial Intelligence • Consumer Web • Digital Media • Information Technology • Social Impact • Software
Build and own evaluation infrastructure, observability tooling, datasets, annotation workflows, and diagnostic systems for production AI agents. Lead experiments across prompts, models, routing, caching, cost, and latency. Diagnose failures across planning, tool use, and agent execution, while partnering with AI Core engineering. Manage and grow the AI Quality team as a hands-on player-coach, contributing directly to production code and technical direction.
Top Skills:
Ai AgentsAnnotation WorkflowsBraintrustCachingCi/CdEvaluation FrameworksLangsmithLlmsModel RoutingObservability ToolingPythonRuby On Rails
What you need to know about the Seattle Tech Scene
Home to tech titans like Microsoft and Amazon, Seattle punches far above its weight in innovation. But its surrounding mountains, sprinkled with world-famous hiking trails and climbing routes, make the city a destination for outdoorsy types as well. Established as a logging town before shifting to shipbuilding and logistics, the Emerald City is now known for its contributions to aerospace, software, biotech and cloud computing. And its status as a thriving tech ecosystem is attracting out-of-town companies looking to establish new tech and engineering hubs.
Key Facts About Seattle Tech
- Number of Tech Workers: 287,000; 13% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Amazon, Microsoft, Meta, Google
- Key Industries: Artificial intelligence, cloud computing, software, biotechnology, game development
- Funding Landscape: $3.1 billion in venture capital funding in 2024 (Pitchbook)
- Notable Investors: Madrona, Fuse, Tola, Maveron
- Research Centers and Universities: University of Washington, Seattle University, Seattle Pacific University, Allen Institute for Brain Science, Bill & Melinda Gates Foundation, Seattle Children’s Research Institute
