Senior Research Associate, Antibody Discovery

SystImmune Inc. is a dynamic clinical-stage bio-pharmaceutical company headquartered in Redmond, WA. Our mission is to revolutionize cancer treatment by developing breakthrough-therapeutic multi-specific antibodies and ADCs. With eight assets in ongoing clinical trials and a robust preclinical pipeline, we are committed to advancing innovative therapies from discovery through IND-enabling stages.

We are seeking a highly skilled and motivated Senior Research Associate to join our Antibody Discovery Group. The successful candidate will play a critical role in supporting the discovery of novel antibodies for therapeutic development. This is a laboratory-based role that utilizes various techniques, including BCR amplification, sequence analysis, and recombinant antibody expression. This position offers an exciting opportunity to work in a dynamic and innovative environment focused on the development of novel therapeutic antibodies.

• Amplify BCR sequences from sorted B-cells.
• Select antibody candidates through BCR sequence analysis.
• Design, clone, and express recombinant monoclonal antibodies.
• Prepare detailed reports and presentations.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Education: Master’s degree in Immunology, Molecular Biology, Biochemistry, or a related field.

Experience:

• 3+ years of hands-on experience in recombinant antibody expression.
• Strong molecular biology background and experience.
• Knowledge of antibody structure, humanization, production, and purification is preferred.
• Hands-on experience in NGS library preparation and BCR repertoire analysis is a plus.
• Experience in antibody discovery and development is highly desirable.

Technical Skills:

• Highly proficient in molecular biology techniques, including PCR (general, nested, etc.), cloning, plasmid DNA isolation, RNA isolation, and sequencing.
• Experience in eukaryotic cell transfection and culture.
• Hands-on experience in humanization of antibodies using various methods.
• Familiarity with sequence data analysis software and statistical tools (Geneious, Discovery Studio).

Soft Skills:

• Effective communication skills, both written and verbal.
• Strong organizational and time management skills.
• Excellent problem-solving and troubleshooting abilities.
• Ability to work independently and as part of a team.

Benefits:

• Competitive salary and performance-based bonuses.
• Comprehensive health, dental, and vision insurance.
• Retirement savings plan with company match.
• Opportunities for professional development and career advancement.
• Collaborative and inclusive work environment.

Join us in advancing cutting-edge clinical pharmacology research and contribute your expertise to our dynamic team!

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
This individual will work in a molecular biology laboratory alongside other scientists and in a standard business office with desktop business equipment and a moderate noise level.

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
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While performing the duties of this job, the employee is regularly required to sit for long periods of time. This individual must be able to operate standard laboratory and business equipment.

The hiring pay range for this position is $75,000 - $110,000 per year based on skills, education, and experience relevant to the role.

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discovery or IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package. 

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.