Senior Scientist - Antibody Discovery

SystImmune Inc. is a dynamic clinical-stage bio-pharmaceutical company headquartered in Redmond, WA. Our mission is to revolutionize cancer treatment by developing breakthrough-therapeutic multi-specific antibodies and ADCs. With eight assets in ongoing clinical trials and a robust preclinical pipeline, we are committed to advancing innovative therapies from discovery through IND-enabling stages.

We are seeking a highly skilled and motivated Senior Scientist to join our Antibody Discovery Group. The successful candidate will play a critical role in advancing our antibody discovery efforts through various techniques, including target analysis, immunogen design, B-cell sorting, flow cytometry, ELISA, and yeast library screening. This position offers an exciting opportunity to work in a dynamic and innovative environment focused on the development of novel therapeutic antibodies.

• Perform in-depth analysis of potential targets, including clinical landscape, biology, protein structure, and literature review.
• Design and execute antibody discovery campaigns from immunization to lead delivery.
• Perform high throughput sorting to isolate specific B cell populations.
• Design, execute, and analyze FACS experiments to validate and characterize antibodies.
• Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing.
• Conduct yeast display library screening to identify and analyze antibody candidates.
• Analyze and compare BCR sequences and immune repertoires.
• Analyze experimental data and prepare detailed reports and presentations.
• Work with cross-functional teams and contribute to project planning and strategy.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Education: Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field.

Experience:

• 3+ years of hands-on experience in B-cell sorting and screening through flow cytometry, ELISA and bio-layer interferometry.
• 3+ years of hands-on experience in yeast library preparation, culture, and screening.
• Knowledge of antibody structure is required; general knowledge of structural biology is a plus.
• Extensive knowledge of B-cell immunology and antibody development.
• Extensive knowledge of cancer immunology.
• Proven contribution to therapeutic antibody development is highly desirable.
• Experience in NGS library preparation and BCR repertoire analysis is also desirable.

Technical Skills:

• Proficiency in flow cytometry and cell sorting techniques.
• Experience in biolayer interferometry (affinity, avidity, binning) or similar assays.
• Strong background in ELISA assay development and optimization.
• Expertise in molecular biology techniques related to yeast display libraries.
• Familiarity with data analysis software and statistical tools (e.g., FlowJo, OCTET, GraphPad Prism, Geneious Prime).

Soft Skills:

• Excellent problem-solving and troubleshooting abilities.
• Strong organizational and time management skills.
• Ability to work independently and as part of a team.
• Effective communication skills, both written and verbal.

Benefits:

• Competitive salary and performance-based bonuses.
• Comprehensive health, dental, and vision insurance.
• Retirement savings plan with company match.
• Opportunities for professional development and career advancement.
• Collaborative and inclusive work environment.

Join us in advancing cutting-edge clinical pharmacology research and contribute your expertise to our dynamic team!

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
This individual will work in a molecular biology laboratory alongside other scientists and in a standard business office with desktop business equipment and a moderate noise level.

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
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While performing the duties of this job, the employee is regularly required to sit for long periods of time. This individual must be able to operate standard laboratory and business equipment.

The hiring pay range for this position is $90,000 - $140,000 per year based on skills, education, and experience relevant to the role.

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discovery or IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.