Baylor Genetics is a clinical genetic testing laboratory that offers a wide range of genetic testing services. Baylor Genetics specializes in providing diagnostic testing, carrier screening, prenatal testing, as well as cytogenetics and biochemistry tests to help healthcare professionals and patients understand and manage genetic conditions.
As we continue to grow and expand our services, we are seeking an accomplished Principal Software Engineer to serve as a technical leader and architect across our software ecosystem. This role is responsible for driving the design, scalability, and evolution of mission-critical systems that support genetic testing workflows, clinical reporting, and data-driven insights. The ideal candidate combines deep technical expertise with strong leadership, systems thinking, and the ability to influence engineering direction across teams. This position will collaborate closely with geneticists, bioinformaticians, laboratory professionals, and product leaders to deliver robust, secure, and innovative software solutions that directly impact patient care.
KEY RESPONSIBILITIES
- Design, develop, and maintain software applications.
- Collaborate with cross-functional teams to define software requirements, specifications, and architecture.
- Document system architecture, processes, and workflows to ensure maintainability and traceability
- Troubleshoot and resolve software defects to ensure system reliability and data accuracy
- Contribute to continuous improvement initiatives and technical innovation
- Adhere to the company’s Code of Conduct and all applicable compliance, security, and regulatory requirements
- Perform other duties as assigned to support team and organizational objectives.
- Comply with all company policies, procedures, and applicable regulatory requirements.
QUALIFICATIONS
Required
- S. or equivalent degree in Computer Science or related field
- 5+ years of professional software development experience
- Strong experience with C# and .NET (e.g., .NET Core / .NET 6+)
- Solid experience building frontend applications with React and TypeScript
- Strong experience with MS SQL Server or equivalent relational database systems (e.g. PostgresSQL, MySQL), including schema design and query optimization
- Experience designing and consuming RESTful APIs
- Strong understanding of software architecture, design patterns, and best practices
- Experience with version control systems (e.g., Git)
- Strong problem-solving skills and ability to work independently
- Equivalent combination of education and experience may be considered.
Preferred:
- Experience in healthcare, clinical diagnostics, or genomics/NGS environments
- Familiarity with laboratory workflows or clinical reporting systems
- Experience working in regulated environments (e.g., CLIA, CAP, HIPAA)
- Knowledge of CI/CD pipelines and DevOps practices
- Experience improving performance in data-intensive applications
COMPETENCIES
- Strong ownership mindset and accountability
- High attention to detail, especially when handling sensitive clinical data
- Ability to communicate effectively with both technical and non-technical stakeholders
- A collaborative team player with mentorship capability
- Sound judgment when balancing speed, quality, and regulatory considerations
- Passion for building tools that directly impact patient care
EEO Statement:
Baylor Genetics is proud to be an equal opportunity employer committed to fostering an inclusive and diverse workplace. We welcome and encourage applicants from all backgrounds to apply. We do not discriminate on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, age, veteran status, disability, genetic information, pregnancy, childbirth, or any other status protected by applicable federal, state, or local law. If you need an accommodation during the application process, please contact our Human Resources team.
Note to Recruiters:
We value building direct relationships with our candidates and prefer to manage our hiring process internally. While we occasionally partner with select recruitment agencies for specialized roles, we do not accept unsolicited resumes from recruiters or agencies without a written agreement executed by the authorized signatory for Baylor Genetics ("Agreement"). Any resumes submitted to Baylor Genetics in the absence of an Agreement executed by Baylor Genetics' authorized signatory, will be considered the property of Baylor Genetics, and Baylor Genetics will not be obligated to pay any associated recruitment fees.
Equal Opportunity EmployerThis employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.
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