Research Scientist II/III, DNA Synthesis

Why Join Us?

Join the #1 DNA synthesis company at the forefront of innovation, leveraging the most advanced technologies in the field. As a member of our team, you will have the opportunity to contribute to groundbreaking advancements drug discovery, biomedical research and synthetic biology. Your work will play a pivotal role in shaping transformative solutions with far-reaching applications, from next-generation therapeutics to cutting-edge diagnostics. Be part of a dynamic, visionary organization where your expertise and creativity will drive meaningful scientific progress.

Role Description:

We are seeking a highly motivated Research Scientist to join our R&D team dedicated to advancing DNA synthesis technologies. This role offers the opportunity to drive innovation in nucleic acid chemistry, oligonucleotide synthesis, and molecular biology. You will play a critical role in optimizing our solid-phase DNA synthesis platform and developing next-generation applications. Your expertise in surface chemistry, analytical techniques, and molecular biology will be integral to shaping the future of DNA synthesis technology.

Key Responsibilities:

• Design and optimize surface functionalization techniques for solid-phase oligonucleotide synthesis.
• Develop next-generation solid-phase DNA synthesis platforms and explore their applications.
• Create novel electrochemical detection assays for oligonucleotide microarrays.
• Characterize complex DNA oligo pools using advanced analytical methods.
• Select and implement techniques to evaluate surface properties and functionality.
• Contribute to nucleic acid chemistry innovations, including phosphoramidite-based and enzymatic oligonucleotide synthesis.
• Optimize all aspects of the company’s DNA synthesis workflows.
• Collaborate with production teams to transfer technology, improve processes, and troubleshoot challenges.
• Perform statistical data analysis and effectively present findings to stakeholders.

Qualifications:

• Ph.D. in Organic Chemistry, Biochemistry, Chemical Biology, or a related field; or M.S. with a minimum of 3 years of relevant industry experience.
• Expertise in nucleoside, nucleotide, and solid-phase oligonucleotide synthesis.
• Strong foundation in organic chemistry and photochemistry.
• In-depth understanding of nucleic acid chemistry and phosphoramidite-based synthesis.
• Hands-on experience with total synthesis, including a variety of purification techniques such as column chromatography, HPLC, and Biotage systems.
• Demonstrated proficiency in handling sensitive or delicate materials (preferred).
• Experience with electrochemical methods and detection technologies (preferred).
• Familiarity with laboratory automation tools and platforms (a plus).
• Advanced molecular biology skills, including PCR, qPCR, hybridization assays, and next-generation sequencing (NGS).
• Proven track record of effective collaboration within interdisciplinary and cross-functional teams.
• Results-driven, with a proactive, hands-on approach to experimental design and problem-solving.
• Excellent written and verbal communication skills.
• Strong documentation skills for drafting technical reports, summarizing experimental data, and supporting technology transfer to manufacturing.
• Highly self-motivated and passionate about driving innovation in the field of biotechnology.

Benefit:

• Medical Insurance/ Vision Insurance/ Dental Insurance
• 401(k) & Retirement Savings Plan (RSP)
• Short Term Disability Insurance
• New Child Leave
• Paid Time Off
• Paid Company Holidays per year
• Paid Sick Days (earned based on hours worked)
• Compassionate Leave
• Jury Duty Leave
• Float day
• Personal days

Perks: 

• Free colleague meals during shift
• Onsite massage Charis
• Onsite gyms

Compensation:
Salary range: $80,000 – $110,000, depending on experience and qualifications.